A first group of passengers, all Spanish nationals and none displaying symptoms of infection, disembarked from the ship into small boats as the vessel approached the Port of Granadilla in Tenerife, Spain’s health ministry said.

Spanish officials said the passengers would be transported in sealed military buses directly to Tenerife’s airport before being flown aboard a government aircraft to Madrid for hospital evaluation and quarantine measures.

Authorities said all passengers would undergo testing by Spanish health officials before onward transport. Foreign nationals are expected to be repatriated in stages using specially arranged flights coordinated by their respective governments rather than commercial air services.

The European Centre for Disease Prevention and Control, or ECDC, classified all passengers and crew as high-risk contacts as a precautionary measure in rapid scientific guidance issued late Saturday. The agency said symptomatic passengers should receive priority medical evaluation and testing upon arrival and may either remain isolated in Tenerife or be medically evacuated home depending on their condition.

Thirty crew members are expected to remain aboard the vessel, which will later sail to the Netherlands for disinfection operations, according to Spanish authorities.The ship departed waters off Cape Verde earlier this week after the World Health Organization and the European Union requested Spain coordinate the evacuation effort following confirmation of the outbreak.

WHO Director-General Tedros Adhanom Ghebreyesus arrived in Tenerife on Saturday alongside senior Spanish ministers to oversee preparations for the ship’s arrival and passenger transfer operations.The WHO said eight people aboard the vessel had fallen ill, including three fatalities involving a Dutch couple and a German national.

Six infections have been laboratory confirmed, while two additional cases remain under investigation.Hantavirus is primarily transmitted through exposure to infected rodents, though health officials say limited person-to-person transmission can occur in rare circumstances.

The WHO has assessed the risk to the wider global population as low while describing the threat to passengers and crew aboard the vessel as moderate.Spanish authorities said evacuation operations were expected to continue throughout the day under strict biosecurity protocols at Tenerife’s Port of Granadilla.

Tedros said he would travel to Tenerife in Spain’s Canary Islands to oversee the disembarkation of passengers, crew members and medical personnel from the Dutch-flagged cruise vessel MV Hondius, which is carrying around 150 people.“I arrived in Spain, where I will join senior government officials in a mission to Tenerife to oversee safe disembarkation,” Tedros said in a post on X.

Three passengers a Dutch couple and a German woman have died after contracting hantavirus during the voyage, while several others have fallen ill, according to health officials.The outbreak has drawn heightened international attention after authorities confirmed infections linked to the Andes virus strain, the only known hantavirus variant capable of transmitting between humans.

Most hantavirus infections are typically spread through contact with infected rodents or their droppings.Tedros said he had remained in direct contact with the ship’s captain, Jan Dobrogowski, and WHO physician Freddy Banza-Mutoka, who is on board the vessel.

“At this stage, there are no additional people on board showing symptoms of hantavirus,” Tedros said, adding that the World Health Organization continued to monitor the situation closely.

He also said the health risk to residents of the Canary Islands and the broader international public remained low.The MV Hondius is expected to dock in Tenerife on Sunday, where Spanish authorities have prepared surveillance and containment measures before arranging special flights to return passengers to their home countries.

Spain’s government said Tedros would meet Prime Minister Pedro Sanchez in Madrid before traveling to the Canary Islands alongside Spain’s health and interior ministers.Spanish ministry officials said the WHO chief would join a command center in Tenerife responsible for coordinating health controls, interagency cooperation and emergency response protocols linked to the ship’s arrival.

The incident has intensified scrutiny over infectious disease preparedness aboard international cruise vessels, particularly involving pathogens with rare but potentially serious transmission characteristics.

A limited hantavirus outbreak linked to an international cruise ship has intensified scrutiny of the United States’ public health preparedness, as scientists and global health officials warn that staffing reductions, laboratory disruptions and political disputes over infectious disease research may undermine responses to future outbreaks.Health experts say the current outbreak remains controllable, with transmission still largely confined to close contacts of infected individuals.

However, the incident has exposed broader concerns about whether public health agencies retain sufficient testing capacity and operational flexibility to respond rapidly if a more dangerous pathogen emerges.According to officials at the World Health Organization, investigators are increasingly focused on evidence suggesting limited human-to-human transmission among individuals who had prolonged close contact with infected patients.

The outbreak has drawn comparisons to a similar hantavirus cluster in Argentina between late 2018 and early 2019, when 34 people tested positive and 11 died. WHO officials said current transmission patterns appear consistent with those earlier cases, including infections involving close family members and healthcare workers.

Maria Van Kerkhove said investigators believe transmission likely occurred between the first infected patients and several close contacts, including a physician who treated patients aboard the cruise ship where the outbreak was first identified.WHO infection prevention specialist Abdirahman Mahamud said aggressive contact tracing, quarantine measures and rapid isolation protocols remain central to containing the outbreak.

He said lessons learned during the Argentina outbreak demonstrated that transmission chains can be interrupted through coordinated public health action.Authorities are now attempting to track passengers from 12 countries, including the United States, who disembarked before the outbreak was identified and later returned home. Epidemiologists said tracing those individuals and anyone they may have contacted while symptomatic remains a critical component of containment efforts.

William Hanage said international coordination may prove more complicated than in previous outbreaks because the passengers dispersed across multiple jurisdictions governed by different public health authorities.Hanage said aggressive contact tracing and quarantine measures would likely be necessary to prevent wider transmission, though he noted that political resistance to such interventions following the Covid-19 pandemic could complicate implementation.

The outbreak is unfolding as US public health infrastructure faces mounting operational and political pressures. Scientists and health officials say laboratory staffing reductions and administrative pauses have already disrupted testing capacity for multiple infectious diseases.According to infectious disease specialist Rochelle Titanji, laboratories responsible for hantavirus testing have experienced staffing cuts, while some federal testing programs have been temporarily suspended.

States currently cannot send samples to the US Centers for Disease Control and Prevention for orthopoxvirus testing, including tests related to mpox, because that division has been paused temporarily, Titanji said. She also noted that federal laboratories can no longer conduct certain diagnostic testing used to determine the specific parasite responsible for leishmaniasis infections.

In April, rabies testing at the CDC was also halted temporarily, according to health officials familiar with the disruptions.At the same time, virology research in the United States has become increasingly politicised. The White House recently issued an executive order restricting certain forms of virus research, while the National Institutes of Health implemented broad funding reductions affecting related scientific work.

US lawmakers have also introduced legislation targeting what they describe as “gain of function” research, a term used in debates surrounding experiments that modify pathogens to study transmissibility or virulence.The debate has intensified amid continuing political disputes over the origins of Covid-19. Although many scientists maintain that available evidence strongly supports zoonotic spillover from animals to humans as the most likely origin of Sars-CoV-2, investigations into possible laboratory-related scenarios continue.

Researchers involved in virology and pandemic studies have increasingly faced subpoenas, investigations and public political scrutiny linked to those debates.Hanage said the current political environment risks weakening scientific preparedness for future outbreaks by discouraging research into zoonotic spillover events.“We should be investing in doing more to understand how these spillover events take place,” he said, adding that current policy trends were moving in the opposite direction.

Public health specialists also expressed concern over legal restrictions adopted in many US states following the Covid-19 pandemic. More than half of US states have enacted laws limiting the authority of public health officials to impose quarantines, recommend masks or enforce certain emergency health measures.Some states have also restricted vaccine requirements for schools and limited the authority of schools to suspend in-person operations during future outbreaks.

Titanji said the relatively limited hantavirus outbreak was already exposing potential weaknesses in outbreak coordination and public compliance. She warned that a more severe pathogen with higher transmission rates or mortality could create substantially greater risks.Despite the United States formally beginning withdrawal procedures from the WHO, the country remains connected to the International Health Regulations framework and continues receiving technical updates and outbreak information from the organisation.

Mahamud said collaboration between WHO officials and US institutions remained active and transparent during the current outbreak response.WHO director-general Tedros Adhanom Ghebreyesus said the outbreak illustrated the continuing importance of international coordination mechanisms during infectious disease emergencies.

He urged both the United States and Argentina to reconsider decisions to leave the WHO, warning that gaps in international cooperation create opportunities for viruses to spread more easily across borders.

The WHO said at least one case of the rare viral infection had been confirmed, with one patient in intensive care in South Africa and two others awaiting possible medical evacuation from the vessel, which is currently stationed off Cape Verde.South Africa’s Department of Health said the first victim, a 70-year-old man, died onboard before his body was removed at Saint Helena.

His wife later collapsed at an airport in South Africa and died in hospital. A third victim remains onboard the ship.The cruise operator, Oceanwide Expeditions, said local authorities in Cape Verde had inspected the vessel but had not authorized disembarkation. Two crew members with symptoms requiring urgent care remain onboard pending further decisions by health officials.

The ship departed Argentina around three weeks ago on a voyage that included stops in Antarctica and the Falkland Islands and was scheduled to end in Spain’s Canary Islands. South African officials said approximately 150 passengers were onboard, along with about 70 crew members.

Hantaviruses are primarily transmitted through contact with infected rodents and can cause serious illnesses, including hantavirus pulmonary syndrome, a severe respiratory condition. While infections are rare, the WHO said limited human-to-human transmission is possible and investigations, including laboratory testing and epidemiological tracing, are ongoing.

A British national who fell ill after the ship left Ascension Island is currently being treated in Johannesburg. South Africa’s National Institute for Communicable Diseases has initiated contact tracing to assess potential exposure among individuals who may have come into contact with infected passengers.

The WHO said it is conducting a full public health risk assessment in coordination with national authorities and the ship’s operator, while medical care continues for those affected onboard.