The U.S. delegation, led by Vice President JD Vance and including special envoy Steve Witkoff and adviser Jared Kushner, was en route to the Pakistani capital after a stop in Paris. The Iranian side, headed by parliamentary speaker Mohammad Baqer Qalibaf and Foreign Minister Abbas Araghchi, arrived on Friday.

Qalibaf said Iran did not trust the United States based on past negotiations and warned that talks would not proceed unless Washington fulfilled earlier commitments, including unblocking Iranian assets and securing a ceasefire in Lebanon.

Iranian officials have linked progress in the talks to developments in the parallel conflict involving Hezbollah, a stance rejected by Washington and its allies.U.S. President Donald Trump said on social media that Iran “has no cards,” adding that Tehran’s leverage was limited to disrupting international waterways.

Vice President Vance, speaking en route, expressed cautious optimism about the negotiations but warned that the U.S. would respond firmly if it perceived bad-faith tactics.The talks come amid a fragile ceasefire announced earlier this week following weeks of U.S. and Israeli strikes on Iran and retaliatory actions by Tehran.

While the ceasefire has paused direct attacks, it has not resolved Iran’s blockade of the Strait of Hormuz, which continues to disrupt global energy flows.Pakistan imposed extensive security measures in Islamabad ahead of the negotiations, with Prime Minister Shehbaz Sharif describing the meeting as “make-or-break.” Thousands of security personnel were deployed across the city.

Parallel tensions persist in Lebanon, where Israeli operations against Hezbollah have continued despite diplomatic efforts. Lebanese President Joseph Aoun has called for a ceasefire as a condition for broader negotiations, while Israeli officials have signaled that upcoming talks with Lebanese representatives in Washington would proceed without linking them to a truce.

Iran has also pushed for broader concessions, including the lifting of sanctions and recognition of its authority over transit through the Strait of Hormuz, a proposal that would significantly alter regional power dynamics. While Iranian vessels were reported to be moving freely through the strait, shipping by other nations remains constrained.

The disruption to energy supplies has contributed to inflationary pressures and slowed global economic activity, with analysts warning that the impact could persist even if negotiations lead to a reopening of the route.Iran’s leadership has maintained a firm stance ahead of the talks.

Mojtaba Khamenei said Tehran would seek compensation for wartime damage and hold those responsible accountable.Despite U.S. claims of degrading Iran’s military capabilities, Tehran retains missile and drone capacity and a significant stockpile of highly enriched uranium, underscoring the challenges facing negotiators in reaching a comprehensive agreement.

In an interview published Monday, Trump said the United States was in talks with Qalibaf, a former Revolutionary Guard commander. Qalibaf denied the assertion in a statement, saying Washington was “promoting desires as news while threatening our nation at the same time.

Iran’s Foreign Ministry also dismissed the claim. Spokesperson Esmail Baghaei said no negotiations had taken place, though he confirmed that intermediaries had conveyed proposals to Tehran.

Baghaei said Iran would not overlook what he described as past breaches of diplomacy, referring to indirect talks in 2025 and early 2026 that were followed by military action involving the United States and Israel.

War pressure shapes diplomacy claimsThe exchange comes as Trump has increased pressure on Tehran to reach an agreement to end the ongoing conflict, now in its fifth week following joint U.S.-Israeli strikes launched in late February.

Trump warned that failure to reach a deal “shortly” could result in widespread destruction of Iran’s energy infrastructure and critical facilities, including desalination plants.

Qalibaf’s role under scrutinyQalibaf, long viewed as a pragmatic conservative within Iran’s political system, has previously been mentioned as a potential interlocutor for Western governments.

However, questions remain about his authority within Iran’s complex power structure following the death of Supreme Leader Ali Khamenei in a February airstrike.His successor, Mojtaba Khamenei, is believed to maintain ties with Qalibaf, though competing centers of power within Iran’s leadership continue to shape decision-making.

Analysts say references to Qalibaf as a negotiating channel may reflect both external pressure tactics and internal political maneuvering, as Tehran navigates wartime conditions and diplomatic isolation.