The Taliban said at least 400 people were killed and 250 injured in the strike, which it said hit a drug rehabilitation hospital, while Pakistan rejected the claim, saying it targeted military installations and “terrorist support infrastructure.

Pakistan had long been a key backer of the Taliban, supporting its emergence in the 1990s as part of a broader strategy to secure “strategic depth” in its rivalry with India.

Relations initially appeared strong after the Taliban returned to power in 2021, with then-prime minister Imran Khan welcoming the development. However, ties deteriorated as Islamabad accused Kabul of failing to curb militant groups operating from Afghan territory.

Pakistan says leaders and fighters of the Tehreek-e-Taliban Pakistan are based in Afghanistan and have intensified attacks inside Pakistan. It also accuses Afghan territory of being used by Baloch insurgents.

Violence linked to these groups has risen steadily since 2022, according to the Armed Conflict Location & Event Data, contributing to mounting pressure on Islamabad to act.

The Taliban deny providing safe haven to militants targeting Pakistan and counter that Islamabad harbours fighters linked to Islamic State, Pakistan rejects.

The latest strike follows weeks of intensifying clashes, including Pakistani air and ground operations targeting Taliban positions and infrastructure along the border. Officials said those actions came after attacks by Afghan forces on Pakistani border posts.

Pakistan’s defence minister has described the situation as amounting to an “open war,” reflecting the scale of the confrontation.Earlier attempts to stabilise the situation, including a ceasefire mediated by Turkey, Qatar and Saudi Arabia, have failed to hold.

Repeated border clashes, closures and disruptions to trade have further strained ties between the neighbours, signalling a breakdown in what was once a closely aligned relationship.

Mohammed bin Zayed Al Nahyan and Abdullah II made the remarks during a meeting in Abu Dhabi on Monday, where they discussed intensifying military activity and its implications for regional security, according to the Jordan News Agency.

The two leaders condemned what they described as Iranian aggression, saying recent attacks targeted their countries and violated sovereignty as well as international law. Their statements were also carried by the Emirates News Agency.

They warned that continued escalation posed risks not only to regional stability but also to global peace and security.Arab stance on conflictBoth leaders reiterated that Arab countries had neither initiated nor participated in the conflict, which they said began on Feb. 28.

Instead, Gulf and broader Arab states have focused on containing the crisis and preventing it from widening.They pointed to ongoing diplomatic efforts by the Gulf Cooperation Council and other regional actors aimed at reducing tensions.

The leaders stressed the need to halt military escalation and prioritise dialogue, urging a return to diplomatic channels to address the crisis.

Their meeting comes amid growing concerns over the spillover effects of the conflict, including threats to national sovereignty and disruptions to regional security dynamics.

The semi-official Tasnim news agency reported that 20 people were detained in northwestern Iran after the provincial prosecutor’s office accused them of transmitting location details of military and security facilities to Israel.

Tasnim also reported the arrest of 10 individuals in northeastern Iran, a region that has so far remained largely untouched by the ongoing air strikes. According to the report, some of those detained were suspected of gathering information about sensitive sites and economic infrastructure.

Iran’s security agencies have intensified internal surveillance and arrests since Israeli and U.S. forces launched a series of strikes against targets in the country. Authorities have repeatedly warned of espionage networks operating inside Iran and accused Israel of attempting to exploit domestic unrest.

A provincial branch of the intelligence organization of the Islamic Revolutionary Guard Corps said Israel and the United States were attempting to activate “mercenaries and spies” to trigger unrest alongside military operations, according to Tasnim.

Separately, the Student News Network reported that three people were detained in the western province of Lorestan on accusations of attempting to “disturb public opinion” and burn mourning symbols.

A source briefed on Israel’s military strategy told Reuters earlier this week that Israeli forces had begun targeting security checkpoints based on tip-offs from informants inside Iran, marking what the source described as a new phase in the military campaign.

In January, weeks before the United States and Israel launched the current war against Iran, the country experienced widespread anti-government protests. Iranian authorities responded with a crackdown that officials described as necessary to restore order, while blaming Israel and the United States for encouraging what they called violent riots aimed at overthrowing the clerical establishment.

The latest arrests underscore Iran’s growing focus on internal security as the conflict widens and authorities seek to curb suspected intelligence leaks and dissent during the ongoing military confrontation.

The Guards said in a statement published on their official Sepah News website that Netanyahu would remain a target of Iran’s forces, accusing him of responsibility for the deaths of civilians amid the ongoing conflict.

“If this child-killing criminal is alive, we will continue to pursue and kill him with full force,” the IRGC said, referring to the Israeli premier.

The statement reflects a sharp escalation in language from Iran’s elite military force as the confrontation involving Iran, Israel and the United States widens. Iranian officials have repeatedly accused Israel of attacks against Iranian interests and leadership figures, while Israel says it is acting to neutralize threats posed by Tehran and its regional allies.

.The IRGC, which answers directly to Iran’s Supreme Leader and wields significant influence over the country’s military operations abroad, has often issued warnings against Israeli leadership during periods of heightened tensions.

The threat comes as the conflict between Israel and Iran-backed forces has expanded beyond their borders, drawing in the United States and affecting multiple countries across the Middle East.

Regional tensions have surged following a series of strikes and counter-strikes involving Israeli forces, Iranian military assets and allied groups.

Governments and international organizations have warned that the conflict risks further destabilizing an already volatile region.

Netanyahu has been a central figure in Israel’s security policy toward Iran, repeatedly warning about Tehran’s military capabilities and its support for armed groups across the Middle East.

Iranian leaders, in turn, have blamed Israel for attacks on Iranian personnel and infrastructure, including alleged covert operations targeting Iranian military and nuclear facilities.

David Sacks, who serves as the White House crypto and artificial intelligence adviser, made the remarks during an appearance on the “All-In Podcast,” describing the current moment as an opportunity for the United States to step back from the conflict.

“This is a good time to declare victory and get out,” Sacks said, adding that U.S. operations had degraded Iran’s military capabilities. He also said Washington should look for what he described as an “off-ramp” to prevent further escalation.

Sacks said avoiding a prolonged conflict would require diplomatic efforts aimed at reducing tensions. “If escalation doesn’t lead anywhere good, then you have to think about how do you de-escalate,” he said. “De-escalation involves reaching some sort of ceasefire agreement or negotiated settlement with Iran.

”The remarks marked a rare public call from a prominent figure within Trump’s administration for an exit strategy from the war, which has intensified regional tensions since late February.

The United States and Israel launched attacks on Iran on Feb. 28, triggering retaliatory strikes from Iran and its ally Hezbollah against Israel and other targets across the Middle East.

The fighting has rattled global financial markets and pushed oil prices higher amid concerns that wider hostilities could disrupt energy supplies from the region.

Iran’s ambassador to the United Nations said more than 1,300 people have been killed in Iran as a result of U.S. and Israeli attacks.

Israeli authorities say Iranian strikes have killed 12 people in Israel.The U.S. military has reported seven service members killed since the conflict began.

The Kurdistan region’s counter-terrorism service said late on Monday that it had shot down three drones over Irbil, with debris from one of the aircraft falling near the UAE consulate. Officials said no casualties were reported.

Saudi Arabia issued a statement through its foreign ministry expressing what it described as its strongest condemnation of the attack targeting the Emirati diplomatic mission.

The ministry said the targeting of diplomatic facilities was unacceptable and reaffirmed Riyadh’s support for measures aimed at maintaining security and stability in the region.

Earlier, the UAE’s foreign ministry said the incident represented a “dangerous escalation” and warned that such actions threaten regional stability.

The ministry said attacks on diplomatic missions and premises constitute a violation of international norms and laws governing the protection of diplomatic facilities.

The UAE urged the Kurdistan Regional Government to investigate the circumstances surrounding the incident, identify those responsible and hold them accountable.

Security authorities in Irbil said the drones had been intercepted before causing casualties, though investigations into the origin of the aircraft and the intended targets were ongoing.