Carriers across Europe, North America and Asia reported widespread suspensions, with routes to key destinations such as Tel Aviv, Beirut and Gulf cities either halted or significantly curtailed.

Greece’s Aegean Airlines said it had cancelled flights to Tel Aviv, Beirut and Amman until April 22, and to Erbil and Baghdad until May 24, while suspending Dubai routes until April 19 and Riyadh until April 18.

Latvia’s airBaltic halted Tel Aviv services until April 5 and Dubai flights until October 24.

Air Canada suspended Tel Aviv flights until May 2 and Dubai routes until March 28, while Spain’s Air Europa cancelled Tel Aviv operations until April 10.

Air France said it had cancelled flights to Tel Aviv and Beirut until March 21 and to Dubai and Riyadh until March 20. KLM suspended services to Riyadh, Dammam and Dubai until March 28 and paused Tel Aviv flights for the rest of its winter season.

Hong Kong’s Cathay Pacific said all passenger and cargo flights to Dubai and Riyadh would remain cancelled until April 30, reflecting continued uncertainty in regional airspace.

U.S. carrier Delta Air Lines said flights between New York and Tel Aviv were cancelled through the end of March, with further suspensions extending into August for some routes.Israel’s El Al said regular flights were cancelled until March 21.

Gulf carriers Emirates and Etihad Airways said they were operating reduced and limited schedules respectively following a partial reopening of regional airspace.

Finnair said it had cancelled Dubai flights until March 29 and Doha flights until April 2, continuing to avoid the airspace of Iraq, Iran, Syria and Israel.

Israel said the missiles dispersed multiple submunitions mid-air, complicating interception efforts. The overnight attack killed two people in Tel Aviv, bringing the total death toll in Israel since the start of the war to at least 14, according to Israeli authorities.

Iran described the strike as a direct response to the assassination of Larijani, one of the most senior figures killed since the conflict began more than two weeks ago. Tehran confirmed his death on Tuesday, following earlier Israeli statements that he had been targeted in an airstrike.

Iran’s Supreme National Security Council, which Larijani had previously headed as secretary, said his son and deputy, Alireza Bayat, were also killed in a separate Israeli attack on Monday night.

In a separate development, Iran said a projectile struck near the Bushehr Nuclear Power Plant on Tuesday evening but caused no damage or injuries. The country informed the International Atomic Energy Agency of the incident.

IAEA Director General Rafael Grossi renewed calls for maximum restraint, warning of the risk of a nuclear accident if strikes continue near sensitive facilities.

The United States and Israel have said their campaign aims in part to prevent Iran from developing a nuclear weapons programme. The strikes have killed multiple senior Iranian officials, including Supreme Leader Ali Khamenei in the opening phase of the conflict.

Iran’s newly appointed supreme leader Mojtaba Khamenei has rejected proposals to de-escalate, according to a senior Iranian official. Speaking at his first foreign policy meeting since taking office, he said it was not the right time for peace and that Iran would continue its confrontation until its adversaries accepted defeat and paid compensation.

The exchange of strikes underscores the intensifying trajectory of the conflict, with both sides expanding targets and rhetoric while international agencies warn of broader regional and nuclear risks.

The latest strike marks another escalation in the widening confrontation involving Iran, Israel and regional armed groups, which has expanded across several fronts in recent days.

Lebanon’s Hezbollah said its fighters were involved in “direct clashes” with Israeli forces late on Saturday in the southern Lebanese town of Khiam.The group said the fighting involved light and medium weapons as well as rocket-propelled projectiles.

Israeli authorities did not immediately comment on the reported engagement.Cross-border exchanges between Israeli forces and Hezbollah have intensified as the broader conflict spreads across the region.

Lebanon is preparing to form a delegation aimed at negotiating with Israel in an effort to halt the war with Iran-backed Hezbollah, a Lebanese official said.

“Negotiations are on the table and preparations are underway to form a delegation, but neither the timing nor the location has been determined,” the official said, adding that Paris and Cyprus were being considered as potential venues for talks.

Israel has not publicly committed to participating in such negotiations.

Lebanon’s health ministry said Israeli strikes had killed 826 people since the start of the latest conflict with Hezbollah, including 65 women and 106 children, while 2,009 others had been wounded.

Turkish Foreign Minister Hakan Fidan said Ankara feared Israel was “moving toward a new genocide under the pretext of fighting Hezbollah” during its ongoing assault on Lebanon.

The Israeli military said in a statement on its official Telegram account that missiles had been launched from Iran toward the State of Israel and that defensive systems were operating to counter the threat.

Air raid sirens sounded across Jerusalem, according to AFP journalists on the ground, who also reported hearing explosions in the distance during the interception attempts.

A short time after the alert, Israel’s military said civilians were permitted to leave protected shelters, indicating the immediate threat had passed.

Israel’s Magen David Adom emergency services said there were no immediate reports of direct casualties from the missile fire. However, emergency teams were treating a small number of people who sustained injuries while moving toward protected areas during the alert.

Israeli broadcaster Channel 12 reported that several people were injured near Tel Aviv following the Iranian missile strikes, though the extent of the damage was not immediately clear.

Iran’s Islamic Revolutionary Guard Corps said it had targeted a satellite communications center in Haifa as well as Israeli military bases during the missile attack.

The Guards also said they struck U.S. targets elsewhere in the Middle East, including locations in Iraqi Kurdistan and the U.S. Fifth Fleet naval base in Bahrain, according to a statement published on the Sepah News website.

In the statement, the Guards said they would continue sustained attacks against what they described as enemy targets during the conflict.